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jueves, 27 de enero de 2022

Los perfiles inmunoproteómicos revelan una regulación celular inmune aberrante en las vías respiratorias de individuos con enfermedad respiratoria continua post-CDV-19

 Los perfiles inmunoproteómicos revelan una regulación celular inmune aberrante en las vías respiratorias de individuos con enfermedad respiratoria continua post-CDV-19

Summary

Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airway and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with elevated concentration of proteins associated with apoptosis, tissue repair and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. 1 year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to ongoing activation of cytotoxic T cells.

Graphical Abstract

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Footnotes

Sir Alexander Fleming Building, National Heart and Lung Institute, South Kensington Campus, Imperial College London, London, UK. SW7 2AZ.

Identification

DOI: https://doi.org/10.1016/j.immuni.2022.01.017

 

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    Graphical Abstract

 

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