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martes, 10 de marzo de 2020

InfoMullet: COVID curiosity. Is a country facing outbreak or containment?







InfoMullet: COVID curiosity. Is a country facing outbreak or containment?



TLDRUpFront: Our mental-model on whether a country is containing the contagion, facing an outbreak, or containing the outbreak can be informed with these charts. We use WHO Daily Situation Reports, and the “outbreak” baseline of China to compare and monitor 35 countries across 7 regions. Bookmark this page and revisit as we’ll be updating data every few days.
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FullContextInTheBack: The last InfoMullet article on COVID-19 introduced two mental-models on COVID-19 contagion of “outbreak” and containment. With more complete data from a WHO investigation of the Chinese outbreak and additional research by the University of Washington we can now locate a threshold zone of risk for the outbreak mode. This allows us to chart countries by region for both total cases and daily rate of change in new cases, comparing them to the China “outbreak” behavior.

Understanding the Charts

This is a quick overview for a lay reader to understand the charts. Or you can skip reading this, go to a chart, post it on Twitter claiming it’s proof of the zombie apocalypse and my sister will get mad at me. So please don’t do that. For a fuller technical description of how we calculated thresholds of risk see “Even More Context in the Way Back” section after the regional data.) For each Region we’ve displayed two charts for select countries: total cases and the daily rate of change. The charts are aligned across the horizontal axis so they all begin at the first day a case was confirmed. This helps compare the behavior of a contagion to another country even if they happened at different times. For example asking “How is my country faring in response or containment at this point in time versus China?” This isn’t just for curiosity sake – countries that fare better containing outbreaks as they happen such as Singapore and South Korea probably have methods we should look at replicating. Plus China appears to have gone through a full outbreak cycle of growth and collapse having now contained the spread. This took about ~65 days and gives us a lifecycle baseline to compare other countries too. Finally pay attention that in the total cases chart, the vertical axis is a logarithmic scale of base ten, so that countries with cases ranging from under 10 to nearly 100,000 can be displayed on the same chart. But don’t misread a line “half-way” up the chart as being halfway to 100,000 – it’s closer to 1,000. What this means is you could still add all the confirmed cases world wide and they probably wouldn’t equal half of what China has already experienced, which is an important sanity check to keep in mind. Whether a contagion is being contained or faces an outbreak, or whether an outbreak is being contained can be understood by several means. First, the steepness of the line as it passes through the threshold of risk. If it is a steep line – as seen in China, Italy, and Iran – then chances of an outbreak that are difficult to contain are high. But if the growth line is mostly flat as it enters the threshold of risk or never reaches the threshold it indicates there may be containment. Both Japan and Singapore show this example. Even if a country has had an outbreak behavior, when we begin to see the growth line in total cases flatten out and the daily rate of change drop, such as in South Korea, that’s a good indication the contagion has been contained. Finally, although total cases tell us where we’ve been, the daily rate of change tells us where we’re going. If the daily rate of change is increasing upward that’s a sign the contagion is accelerating. But if it’s declining, that’s a sign the contagion is being contained. This data however can be very ‘noisy’ in the early stages when there are few cases, so a growth rate of 100-200% might occur if the country got its testing act together.

Caveat Lector the Deuce

Same caveats apply as the last article. This is intended to improve mental models and not for peer review. Specifically we are only charting the data the WHO provides in it’s Daily Situation Reports.(1) This means if a country is actively suppressing information it may not look bad until it is bad. Lack of available testing kits may also make some countries look “better” than others that are testing more people, and catching more cases. This data should be treated as notional and illustrative. And keep in mind that even in the cases of an outbreak we know from China what that looks like and have conducted forecasts within ambiguity for the United States, an “outbreak” does not mean the zombie apocalypse has arrived. Just that containing the contagion is going to prove very difficult until it burns itself out.

COVID-19 by Region

North America

We’ll start with North America. As of today, it looks like the United States could be heading to an outbreak behavior. Bear in mind however that this aggregates all the United States into one country and with the geographic expanse we could combining several containable contagions into one number that looks at outbreak. On the other hand, conflicting guidelines on who should be tested, and a lack of testing kits for the early part of the crisis may mean that across the board cases are being systemically under reported.






Northern Europe

Outside of China, Europe is struggling the most to contain the contagion. In Northern Europe Germany is crossing the threshold risk with BeNeLux (Belgium, Netherlands, and Luxemborg) and Nordic countries (Iceland, Findland, Sweden, Norway, Denmark, and Greenland) not far behind entering the same risk area. This is worrying because BeNeLux and the Nordic countries are a fraction of the size of Germany, so comparatively they are getting hit worse. However, they may also be reporting more cases because they have more testing kits and are being more expansive in their testing protocols – so bear that in mind.





Southern Europe

Southern Europe, especially Italy, are struggling to contain the contagion. Italy’s recent measures of mass quarantines are being widely reported and the chart shows why. Italy’s growth entered the risk threshold and has already cleared it and is still growing strong. France, Spain, and Switzerland are also now in, or entering, the risk zone, all with steep growth which implies they will enter an outbreak mode.






South Asia

There aren’t many confirmed cases in South Asia. Singapore demonstrates an excellent example of a contained outbreak. And India, Pakistan, and Bangladesh are all reporting only a handful of cases. This could be good news, that a combination of unfavorable environmental and demographic conditions mitigates the spread. But given that these countries also have massive populations, often living in close proximity, and often with inadequate access to healthcare we’d caution against too rosy an estimate. It may be that the contagions are just now starting, or that cases and fatalities are not being reported, there’s not enough testing available, governments are hiding numbers – or a combination of all of the above.





East Asia

The first region struck by the contagion, East Asia provides an excellent case study in comparing the behavior modes across the three countries. South Korea had an outbreak but appears to be successfully containing it at a level far below China’s, without resorting to authoritarian measures. There’s a lot of good lessons to learn from this. Japan doesn’t appear to be threatened by a breakout. Even as its cases climb towards the risk threshold it’s at a fairly flat incline.





Middle East

The most hard-hit country in the Middle East is Iran. Interestingly it’s behavior curve begins sooner in the outbreak cycle, and is steeper, than China’s. This may be because of local factors but could also represent the Iranian regime suppressing information until it could not be hidden anymore. The GCC stands for the Gulf Cooperation Council which includes Saudi Arabia, Kuwait, Qatar, Oman, Bahrain and the United Arab Emirates.





South America

We’ve added South America as a placeholder – but there’s not much to report yet as far as WHO Data is concerned. Brazil, Ecuador and Argentina have less than 50 cases between them and other countries are all in single digits.





Even More Context in the Way Back: Determining the Threshold of Risk

In the first article we presented two hypothetical behaviors of daily new cases, shown below.





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In the outbreak mode, in red marked #1, a contagion of daily new cases grows exponentially at a high rate over time, but then collapses just as quickly. For reasons discussed in our first article, the contagion burns itself out. In a containment mode, marked with #3 , daily new cases grow more slowly and diminish more gradually. The area under either curve represents the total cases, which when plotted would appear as an S-Curve. We’ve now seen China go through this entire cycle as the first nation to deal with COVID-19 and can plot their actual data to recreate the hypothetical charts above. One piece of key data we were missing until last week was where to locate a threshold of risk to understand whether a contagion would manifest in containment or outbreak mode. Researchers at the University of Washington & the Fred Hutchinson Research center however compared Seattle, WA to Wuhan (based on WHO Data) and found:
“We know that Wuhan went from an index case in ~Nov-Dec 2019 to several thousand cases by mid-Jan 2020, thus going from initial seeding event to widespread local transmission in the span of ~9-10 weeks. We now believe that the Seattle area seeding event was ~Jan 15 and we’re now ~7 weeks later. I expect Seattle now to look like Wuhan around ~1 Jan, when they were reporting the first clusters of patients with unexplained viral pneumonia. We are currently estimating ~600 infections in Seattle, this matches my phylodynamic estimate of the number of infections in Wuhan on Jan 1. Three weeks later, Wuhan had thousands of infections and was put on large-scale lock-down.”(2)
Note they are describing estimates of actual cases, not confirmed. Using their timeline however we took the total confirmed cases reported in China by WHO along their timeline and located the band centered at 800 confirmed cases in the top chart and 40% growth rate in the bottom chart. The band extends up and down to represent both uncertainty and differences between locations. It’s a notional indication at best, but looking through the charts it does seem that those countries which cross the band at a steep line end up in an outbreak pattern, while those who avoid it or enter it on a flatter growth pattern have contained the contagion.

Sources

(1) https://github.com/CSSEGISandData/COVID-19 (2) https://bedford.io/blog/ncov-cryptic-transmission/


Explicacion de Ignacio Martinez Lejarza Esparducer.:

Mientras en China la evolución, desde el primer día con algún caso ,sigue un crecimiento logístico "de libro" ,en la inmensa mayoría de los países, se pasa por un cierto periodo de meseta, de entre 15 a 20 días, antes de dispararse el crecimiento del contagio de forma algo más acelerada de lo esperado. Muy pocos países ( Suiza y algún otro que no muestro y el conocido de Irán) no presentan esta anomalía "mesetaria". Presentan otra peor crecen "casi verticalmente" desde el principio. 
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 ¿por qué la aceleración gradual habitual que prevé la curva logística sólo se ha dado en China mientras en el resto de paises se contiene 15 días y luego "explota" ?
Me temo que China nos ha ganado por la mano. 

*Segun Ignacio es preocupante el "mesetarismo" este tan "peligroso".
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NOTA: La logística es una curva de evolución muy estudiada que crece aceleradamente al principio pero hasta un punto a partir del cual que empieza a crecer con ,cada vez menor aceleración, hasta que finalmente deja "casi" de crecer.

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Via del muro de Ignacio Martinez Lejarza Esparducer
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RM:Este virus es nuevo, y no sabemos bien aun como se comporta, quizas se comporte de diferente forma en cada pais,  quizas se expande de diferente forma


Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in ChinaSummary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Author Affiliations Article Information
JAMA. Published online February 24, 2020.


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