El ejercicio físico libera un gran conjunto de proteínas (secretoma celular) que actúan beneficiosamente en múltiples tejidos. Más de 200 moléculas que ejercen efectos terapéuticos mejorando la salud. 

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

• Wei Wei ¹⁵
• Nicholas M. Riley ¹⁵
• Xuchao Lyu ¹⁵
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• Michael P. Snyder
• Carolyn R. Bertozzi
• Jonathan Z. Long ¹⁶

Highlights

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  An organism-wide cell-type-specific secretome atlas after exercise training in mice
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  Exercise training induces cell-type-specific and bidirectional secretome changes
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  Pdgfra+ cells are highly responsive to exercise training
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  Secreted CES2 proteins improve metabolic health and enhance running endurance

Summary

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.

Graphical abstract

• https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00138-9