13 recent scientific breakthroughs

From photos of the infant universe to an energy advancement that could save the planet Petri dish illustration

Researchers have reported a dizzying number of recent discoveries and achievements

(Image credit: Suzanne Bainton/Getty Images)

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    1. Primer trasplante de riñón de cerdo
    2. Terapia celular para el melanoma
    3. FIV con rinocerontes
    4. Configuración prístina
    5. Restauración de arrecifes
    6. IA para encontrar alienígenas
    7. Vacunas inversas
    8. Secuenciación del cromosoma Y
    9. Descubrir el movimiento del espacio-tiempo
    10. Terapia génica para la distrofia muscular
    11. Mejorar la salud del corazón
    12. Lectura de la mente por IA
    13. Frenar el Alzheimer
https://theweek.com/health-and-science/1019386/recent-scientific-breakthroughs

By Devika Rao, The Week US

published January 31, 2024

Contributions from

Harold Maass, The Week US

Scientists in many fields received little recognition for the last couple of years, as the world focused on the emergency push to develop vaccines and treatments for Covid-19. But that doesn't mean they weren't still busy researching a dizzying series of developments that are now being reported as major discoveries and achievements.

1. First pig kidney transplant

Scientists successfully transplanted a pig's kidney into a human. If the organ takes successfully, it could be a game-changer for those waiting in vain on the kidney transplant list. "I saw it not only as a way to help me, but a way to provide hope for the thousands of people who need a transplant to survive," said Richard Slayman, who received the transplant, to The Associated Press. The surgery took four hours and 15 people to execute.

Pigs have long been used in medicine for procedures like skin grafts and implantations of heart valves. However, "transplanting entire organs is much more complex than using highly processed tissue," said the AP, adding that the pig was "genetically edited to remove harmful pig genes and add certain human genes to improve its compatibility." Slayman now needs to be monitored for any rejection of the kidney. "He would have had to wait five to six years for a human kidney. He would not have been able to survive it," Dr. Winfred Williams, an associate chief of the nephrology division at Mass General, said to The New York Times.

The U.S. Food and Drug Administration (FDA) approved the first cellular therapy for aggressive forms of melanoma. The treatment, called Amtagvi, is "designed to fight off advanced forms of melanoma by extracting and replicating T cells derived from a patient's tumor," said NPR. These cells are also called tumor-infiltrating lymphocytes (TIL). T cells are integral in the immune system but can become "dysfunctional inside tumors.

"The approval of Amtagvi represents the culmination of scientific and clinical research efforts leading to a novel T cell immunotherapy for patients with limited treatment options," Dr. Peter Marks, the director of the FDA's Center for Biologics Evaluation and Research, said in a statement. The treatment won't work for everyone, but research by the National Institutes of Health showed a "56% response rate among patients with melanoma, and 24% of patients had a complete disappearance of their melanoma, regardless of where it was," Axios said. "This is the tip of the iceberg of what TIL can bring to the future of medicine," Patrick Hwu, CEO of Moffitt Cancer Center, said to Axios.

Scientists were able to impregnate a southern white rhino using in-vitro fertilization (IVF). Researchers in Kenya implanted a southern white rhino embryo into another of the same species using the technique in September 2023, resulting in a successful pregnancy. The technique could be used to save the northern white rhino from total extinction. "We achieved together something which was not believed to be possible," Thomas Hildebrandt, head of the reproduction management department at the Leibniz Institute for Zoo and Wildlife Research, said in a press conference.

There are two species of white rhinos: northern and southern. The northern white rhino is on the verge of extinction due to poaching, with only two females remaining. Luckily, scientists have sperm preserved from the last male rhino, which could be combined with an egg from the female and implanted into a southern white rhino female to act as a surrogate. Using a white rhino embryo to test the procedure was a "proof of concept" which is a "milestone to allow us to produce northern white rhino calves in the next two, two and a half years," Hildebrandt said.

Scientists discovered six exoplanets that revolve around a star in a rare pattern called orbital resonance, said a study published in the journal Nature. This means that "for every six orbits completed by planet b, the closest planet to the star, the outermost planet g completes one," CNN said, adding that "as planet c makes three revolutions around the star, planet d does two, and when planet e completes four orbits, planet f does three."

The system was deemed a "rare fossil" by Rafael Luque, a postdoctoral scholar in the University of Chicago's Department of Astronomy and Astrophysics. "We think only about one percent of all systems stay in resonance," Luque said in a statement. "It shows us the pristine configuration of a planetary system that has survived untouched." The discovery could help further the study of sub-Neptunes, which are planets larger than Earth but smaller than Neptune. They are not present in our solar system. "There is little agreement among astronomers about how these planets form and what they're made of — so an entire system consisting of sub-Neptunes could help scientists determine more about their origin," Luque said.

Warming oceans and rising temperatures are the largest contributors to coral degradation. "One of the things that we do in this lab is subject them to different environmental conditions and evaluate who's a little bit stronger," Ian Enochs, lead of the Coral Program at the Atlantic Oceanographic and Meteorological Laboratory at the National Oceanic and Atmospheric Administration, said to NPR. Researchers created a "complex matrix of aquariums" where they can "subject different types of corals to different environments and not only understand how they might survive, but perhaps help them to do so."

Scientists have created an artificial intelligence model that can detect alien life, said a study published in the journal PNAS. The algorithm can "distinguish between samples of biological and nonbiological origin 90% of the time," after being "trained using living cells, fossils, meteorites and lab-made chemicals," Live Science said. "Put another way, the method should be able to detect alien biochemistries, as well as Earth life," Robert Hazen, co-author of the study, said in a statement.

The AI "does not involve a machine having to look for specific things," but rather "looks for differences between samples," BBC said. "These results mean that we may be able to find a lifeform from another planet, another biosphere, even if it is very different from the life we know on Earth," Hazen continued. "And, if we do find signs of life elsewhere, we can tell if life on Earth and other planets derived from a common or different origin."

Scientists may have found a way to calm immune responses for those with autoimmune disorders using an "inverse vaccine," said a study published in the journal Nature Biomedical Engineering. The immune system responds to specific identifying markers on invaders like viruses and bacteria called antigens, "but some immune cells react to self-antigens," which are "molecules from our own cells," said Science. "In autoimmune diseases, these misguided immune cells turn against patients' own tissues."

The new research worked by "directing potential self-antigens to the liver," where "immune cells there pick up self-antigens and then stifle T cells that could target these molecules." The experiment was performed on mice. "The method they use is promising and potentially can induce better tolerance," neurologist and neuroimmunologist A.M. Rostami said to Science, adding that "we don't know" whether this approach is "applicable to human disease in which we don't know the antigen."

Scientists found evidence that the fabric of space and time gets warped by gravitational waves. "What we measure is the Earth kind of moving in this sea," astrophysicist Michael Lam said to The Washington Post. "It's bobbing around — and it's not just bobbing up and down, it's bobbing in all directions." The findings affirm a facet of Einstein's Theory of Relativity that "space is not serenely empty, and time does not march smoothly forward," the Post said.

What scientists discovered was the "low-pitch hum of gravitational waves resounding throughout the universe," and the findings were published in The Astrophysical Journal Letters. While the cause of the hum is not certain, scientists believe it originated from supermassive black holes circling each other, said The Wall Street Journal. "Before now, we didn't even know if supermassive black holes merged, and now we have evidence that hundreds of thousands of them are merging," said Chiara Mingarelli, a Yale University astrophysicist and a member of the North American Nanohertz Observatory for Gravitational Waves (NANOGrav), which led the research, to the Journal.

A daily pill, bempedoic acid, has proved its ability to reduce the risk of heart disease, especially in those who have adverse reactions to statins, said a study published in the New England Journal of Medicine. Statins are normally prescribed to reduce cholesterol; however, many individuals cannot take them or choose not to take them because of side effects. "Statins are known to cause muscle aches in a subset of people," said USA Today.

"We don't like to use the term mind reading," Alexander Huth, who worked on the research, said to CNN. "We think it conjures up things that we're actually not capable of." He said the "real potential application of this is in helping people who are unable to communicate." To allay any concerns about whether the technology could pose a threat to privacy once further developed, Jerry Tang, the lead author of the paper, said everyone's brain data should be private. "Our brains are kind of one of the final frontiers of our privacy."

A drug from pharmaceutical company Eli Lilly showed signs of slowing the advance of Alzheimer's disease by approximately one-third, BBC said. The drug, called donanemab, acts as an antibody specifically created to attack and remove "sticky gunk" called beta-amyloid, which "builds up in the spaces between brain cells, forming distinctive plaques that are one of the hallmarks of Alzheimer's," BBC said. "We are now entering the time of disease modification, where we might realistically hope to treat and maintain someone with Alzheimer's disease, with long-term disease management rather than palliative and supportive care," Dr. Cath Mummery of the U.K.'s National Hospital for Neurology and Neurosurgery said to the outlet.

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sábado, 6 de abril de 2024